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<p>Unlike the test cyp of today, the original Depo-Testosterone was used for more than just curing low testosterone production issues. It was used, for example, for treating benign polycystic ovarian syndrome, or PCOS, which means that a woman can't become pregnant while she's on oral testosterone replacement, though her levels usually increase when the drug is taken after a hysterectomy. Because the test can't show a woman's actual levels of testosterone, it's not a screening test, but rather a measurement of a woman's hormone levels. Today's Depo-Testosterone is far more advanced, but at the same time many scientists don't see it as particularly helpful.

That's partly because the test is far more invasive than the test today, so much so that some physicians think testosterone itself has become a safety issue in today's medical world. Testosterone is injected into the testes of women to suppress, for example, the production of a hormone that can cause serious health problems in the developing fetus.

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But testosterone does have another side effect—it's an aphrodisiac. The same Johns Hopkins researchers whose research in animals suggests that low testosterone levels can cause sleeping problems in humans reported that mice who ate testosterone were more likely to mate successfully.

In 2010, a team of researchers at Johns Hopkins did another experiment with mice. They found that an injection of testosterone led to a dramatic drop in cortisol and elevated estradiol. This was especially fascinating because estrogen is produced by both men and women, but it also seems to increase fertility—and by increasing the chances of successful reproduction, testosterone might have added some reproductive health benefits to the test. It's yet to be determined whether testosterone also acts as a contraceptive when taken as prescribed for people with PCOS, and whether the same effect might be observed in women.

The bottom line, though, is that there's pretty high variability in people's levels of testosterone and hormone-production, and that's why medical professionals tend to advise women to take their testosterone level as low as possible. The real answer is that the levels you're given today often don't represent your actual level of testosterone.</p>
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