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<p>Many athletes use anabolic-androgenic steroids (aas) for physical enhancement but the magnitude of these gains and associated adverse effects has not been rigorously quantified. In the present study, we have quantified the acute and chronic effects of aas on male cyclists. Sixteen male cyclists were divided into two experimental groups. Two groups of cyclists used placebo to achieve maximal blood and urine output on the day of a 5.2-km cycling race at 40–60 % VO2max (VO2max) in cycling-specific (CT) mode for 30 d. Control cyclists completed 6.5 d of a similar course at 50–70 % VO2max (VO2max). During the second 6.5-d phase, a series of six cycles of different aas protocols (1, 10, 40, 60, 80, and 100 µg·kg(-1)·d(-1) of testosterone enanthate or placebo, respectively) was performed 4 times in each group. The testosterone aas protocols consisted of four aas protocols (a-200 mg, a-100 mg, a-25 mg, and a-10 mg) in two equal doses. A-200 mg took 45 min to reach plasma levels of testosterone and a-100 mg took 15 min to reach 0.75 nmol testosterone. PPT PowerPoint slide

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larger image TIFF original image Download: Figure 3. Chronic (a-200 mg) and acute (a-100 mg) effects of aas on male cyclists. (A) A-200 mg was administered 2 h prior to a 5.2-km individual time trial with the cycle lengths of 50–90% VO2max (VO2max), a low-intensity (50–80 % VO2max) individual run at an intensity level of 5 W (W) and 40% VO2max (W/60%) under treadmill exercise conditions. The mean age of the subjects was 29 ± 1 y in the placebo (n = 7) and a-100 mg (n = 5) aas groups. The aas groups (15 subjects) were trained using both a-5 mg aa and a-5 mg aa-20 mg aa twice daily, for 3 weeks and on a daily basis. (B) The same protocol was performed but the average age of the subjects was 28 ± 2 y in the placebo group. (C) The mean of 24 subjects for the 5.2-km TT during 60 % VO2max. PPT PowerPoint slide

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