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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteronegel. The control group was administered placebo until it was clear that any side-effects were more severe in both the interventions and the active group. The two groups were equally matched for age, body mass index, education and health. The men did not receive hormone treatment, nor did they have diabetes, high blood pressure or asthma. The men were given the same medical history and were asked to maintain a healthy diet. One week before the study the men were interviewed by a psychologist about their diet, eating habits and alcohol consumption. The group receiving the testosterone gel was asked to return after four weeks to return to the psychologist to receive a 'no intervention' questionnaire, allowing them to answer any questions that might have influenced their findings.
After the four weeks of treatment the group was again visited by a psychologist until they returned, but without diet or medication information, to again return to the psychologist for a 'no intervention' question. This followed up every four weeks thereafter. The two groups were compared using the Kruskal–Wallis and Wilcoxon signed-rank test at weeks four and eight. As they had before, participants in the weight loss therapy groups had much greater fat mass loss after two or four weeks compared to placebo and testosterone group. After four weeks there was a significant time by group comparison for waist circumference in all groups. For example, there was a trend across groups in week four for men in the testosterone group to shrink their waist circumference compared to placebo, but not significant. For women the opposite pattern was seen - there was a significant time by group analysis between week four and week six for both groups, however, for the estrogen group, the effect was larger in the last week of the protocol (day six). Similarly, for men in the weight loss groups waist circumference grew faster over time than placebo and testosterone treatment did, with no difference in waist circumference in any group.
A greater reduction in waist circumference was associated with greater fat loss, suggesting a potential mediating effect of testosterone on metabolic changes in men. However, there was no significant differences between the groups in this relation. There was a significant time by group comparison of waist circumference in the groups in subsequent analyses. For men receiving testosterone there was a reduction in waist circumference of 0.8 centimeters compared to placebo that was significant over time for women.
'The results suggest that weight loss therapy with T may be effective and are of interest to clinicians and scientists looking at obesity and a variety of metabolic conditions,' conclude lead author of the study Dr Matthew Phelan
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